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ARPKD/CHF Alliance Awards Grant for Fibrosis Research


The ARPKD/CHF Alliance ( is pleased to announce a Research Grant of $50,000 was awarded to Dr. Rebecca Wells, M.D., Assistant Professor of Medicine (Gastroenterology) and Pathology and Laboratory Medicine at the University of Pennsylvania, to study the fundamental mechanism of non-inflammatory fibrosis, unique to CHF. Such research results are critical to therapies and may have implications for other liver diseases.

The title of her project is: TGF-B Signaling and Cell-Cell Interactions in Congenital Hepatic Fibrosis. (

Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease occur together, creating a chronic and progressive disorder that cause high infant mortality. There are no treatments or cure. Hepatic or liver fibrosis and its complications are increasingly important as individuals with ARPKD/CHF grow older and survive beyond the neonatal period.

The ARPKD/CHF Alliance received 10 Letters of Intent and 4 excellent, full research proposals upon invitation. These were reviewed by the ARPKD/CHF Alliance Research Committee utilizing NIH Gold Standard Criteria. The ARPKD/CHF Alliance is a nonprofit, public charity, and the only organization in the world solely dedicated to ARPKD/CHF.

To learn more, visit us at, or email or call us at or 1-800-708-8892.


 pkd, arpkd, chf
 autosomal recessive
 hepatic fibrosis
 liver fibrosis
 polycytic kidney

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