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New Laboratory for Mutagenicity and Cytoxicity Reference Testing


Aniara Mutagenicity & Cytoxicity Reference Testing Laboratory In Partnership With Canadian Research Center CRBM-MBRC is now availabe as a resource to use for mutagenicity and cytoxicity testing of new compounds worldwide.

Ames Testing
The CRBM-MBRC Research Center in Rimouski, Quebec Canada, features a fully equipped laboratory for performing an optimal Ames II™ Mutagenicity Assay, and reporting work for customers. Chemicals will be accepted to perform the required assays, interpret data, and produce detailed reports. The staff is fully trained in all aspects of the Ames II™ Mutagenicity Assay, providing a very efficient and cost-effective process.

Rapid turnaround
Assay data without capital investment or training
Detailed data reporting
Standard Operating Procedure protocols
A fully interactive process
Full confidentiality
Unused compound return
Customizable assay formats
The staff understands all aspects of the Ames II™ Mutagenicity Assay performance, using the most appropriate equipment for each step. As a result, you can expect the most out of each assay performed. The staff is also trained to troubleshoot all aspects of the Ames II™ Mutagenicity Assay, and can advise you on the assay modifications most likely to yield the best data for a given set of chemicals.

Each test compound is tested in six concentrations, in triplicate.
Positive and negative control drugs are run per microplate.
S9 metabolic fraction is tested with, and without, each test compound.

Cytoxicity Testing

The CRBM-MBRC facility is fully equipped laboratory for performing Cytoxicity testing using the in vitro methods developed by Xenometrix. The test kits are utilized to determine protein synthesis, membrane permeability, and respiratory or lysosomial activity.

Complete range of Cytoxicity markers
Single and multiple parameters from one cellular sample
High throughput screening methods
Reduced amount of test compound and cells with the multiple parameter test kits
Testing services currently available for:

The Ames II™

Ames II™ Mutagenicity Assay Systems

Four Parameter Cytotoxicity Test Kits
Three Parameter Cytotoxicity Test Kits
Custom made to specification
Two Parameter Cytotoxicity Test Kits
One Parameter Cytotoxicity Test Kits
CVDE Crystal Violet Dye Elution
GLU Glucose
LDHe Extracellular Lactate Dehydrogenase
MTT Diphenyltetrazolium Bromide
NR Neutral Red
PAC Acid Phosphatase
SRB Sulforhodamine B
XTT Tetrazolium Hydroxide
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