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Epigentek Offers a Complete Kit Series for Quantifying Both Global DNA Methylation and Hydroxymethylation


NEW YORK, Sep 2 - Epigentek Group Inc. announced today that it released two more products in its MethylFlash(TM) series to complete its line of kits for studying global DNA methylation. These two new MethylFlash(TM) Methylated DNA Quantification Kits are based on a new method for quantifying global DNA methylation; one is for a colorimetric procedure and the other is for a fluorometric procedure. The method enables background signals to be extremely low which eliminates the need for plate drying and blocking, allowing the kits to become more simple and convenient to use.

These kits can be used for quantifying methylated DNA in a high throughput microplate format using DNA samples from any species including mammals, plants, fungi, bacteria, and viruses, and are also optimized for paired use with the MethylFlash(TM) Hydroxymethylated DNA Quantification Kits (first launched back in late June) for simultaneously quantifying both methylated and hydroxymethylated DNA.

Epigentek’s technical expertise in DNA methylation have been reinforced over the last four years by its offering of the kits’ predecessor, the popular Methylamp(TM) Global DNA Methylation Quantification Kit, which have been cited by scientists in many high profile journals.

Because of the presence of both 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in DNA with possibly different functions, it is necessary to determine the contents of 5-mC and 5-hmC and their ratios in different cell types and in different compartments of the genome of mammalians. It is particularly important to identify the true status of epigenetic change at the DNA level in diseased human cell/tissues -- is it methylation or hydroxymethylation? Because the true status of global DNA methylation can only be determined when 5-hmC is accurately distinguished from 5-mC, the MethylFlash(TM) kits have significant importance by identifying, distinguishing, and quantifying both global DNA methylation (5-mC) and hydroxymethylation (5-hmC).

Epigentek is recognized for being an innovation leader in epigenetics by spearheading novel, convenient, and affordable methods with its products. By circumventing the need for expensive and cumbersome mass spec and HPLC-based methods, the MethylFlash(TM) kits enables essentially every lab to be able to participate in DNA methylation and hydroxymethylation research and contribute its findings to the epigenetic community.

About Epigentek Group Inc.
Epigentek is a leading biotechnology company that focuses on developing and providing innovative technologies and products as a complete and systematic solution for epigenetic related research and drug discovery. Visit our informative website at


 DNA methylation
 DNA hydroxymethylation

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