Dow Foam Granulation Technology™ for Innovative Tablet Manufacture Used in Second Drug Candidate at Bristol-Myers Squibb

Midland, MI - Dow Wolff Cellulosics, a business unit of The Dow Chemical Company and its affiliates, today announced that a second drug candidate developed by Bristol-Myers Squibb Company (NYSE: BMY) will use Dow’s Foam Granulation Technology™ (FGT) in the development and manufacturing of tablets intended for clinical and commercial use.

“This new drug candidate confirms that the benefits and advantages of Dow’s FGT versus existing granulation technologies are clear,” said Hirotsugu Furukawa, global market manager for pharmaceuticals at Dow Wolff Cellulosics. “This new technology allows for fast, simple, and cost effective granulation and could help minimize issues associated with conventional processes. Without modifying existing equipment and using a low-cost foam generator, the manufacturing process uses less water than traditional wet granulation processing while rapidly coating particle surfaces and shortening processing time.”

The inherently large surface areas of foams provide more efficient particle coverage than may be achieved by conventional spray technology. Elimination of spray nozzles removes some of the variables that are commonly encountered in spray granulation. It has been observed by Dow Wolff Cellulosics that particle size distribution is virtually unaffected by foam addition rate; this leads to a dramatic simplification in product scale-up. Drug content uniformity is also improved which is especially important in low-dose formulations. Dow Wolff Cellulosics offers multi-functional excipients – METHOCEL™ and ETHOCEL™ cellulose ethers WALOCEL™ sodium carboxymethyl cellulose, and POLYOX™ poly(ethylene) oxide resins – that have been used in pharmaceutical formulations for more than 40 years including applications such as controlled release, tablet coating, hot melt extrusion and granulation. Additional specific information can be found on www.dowwolffcellulosics.com.

About Dow Wolff Cellulosics

A preferred development supplier in its industries, Dow Wolff Cellulosics provides highperformance cellulose derivatives and complementary chemistries, and has experience in formulation know-how for a broad variety of end-use products in construction, food, personal care, pharmaceuticals, paint and other specialty industrial applications.

As an affiliated company of The Dow Chemical Company, Dow Wolff Cellulosics GmbH was created on July 01, 2007 as a new business encompassing the cellulose activities of Wolff Walsrode AG and Dow’s Water Soluble Polymers business. More details about Dow Wolff Cellulosics are on the Web at www.dowwolffcellulosics.com.

About Dow

With annual sales of $54 billion and 46,000 employees worldwide, Dow is a diversified chemical company that combines the power of science and technology with the “ Human Element ” to constantly improve what is essential to human progress. The Company delivers a broad range of products and services to customers in around 160 countries, connecting chemistry and innovation with the principles of sustainability to help provide everything from fresh water, food and pharmaceuticals to paints, packaging and personal care products. References to “Dow” or the “Company” mean The Dow Chemical Company and its consolidated subsidiaries unless otherwise expressly noted.