Elsevier MDL Releases Enhanced MDL® Notebook 2.0

SAN RAMON, CA — October 3, 2006 — Elsevier MDL, the market leader in discovery informatics and workflow integration for the life sciences and chemical industries, announces the release of a substantially enhanced version of MDL® Notebook, its state-of-the-art electronic laboratory notebook (ELN). Built on the MDL® Isentris® system, MDL Notebook supports a broad range of chemistry experiments from the single-step synthesis of discrete molecules to multi-step synthesis and complex parallel chemistry experiments.

“Efficient data capture and integration are increasingly critical in the research and development of new chemical entities,” said Dr. Trevor Heritage, senior vice president and chief scientific officer at Elsevier MDL. “By enabling scientists to build searchable experimental repositories quickly and easily, and share information in a straightforward manner, the latest release of MDL Notebook lets scientists work smarter, not harder, in an advanced e-R&D environment. It is a major step in the development of an ELN optimized for chemistry workflows in the short term that will ultimately be suitable for biologists too.”

MDL Notebook integrates smoothly with the critical laboratory systems, workflow applications and content sources chemists use every day, including the MDL® Available Chemicals Directory sourcing database, the MDL® Logistics reagent management system, the new MDL® Registration system for creating corporate compound registries and the DiscoveryGate® content platform.

Integration with DiscoveryGate enables researchers to access key data sources for investigating the synthesis and properties of target substances, including the MDL synthetic methodology and bioactivity databases, the essential Beilstein chemistry reference and valuable EH&S information from Elsevier MDL OHS.

With over 25 years of experience building large, electronically searchable reaction databases and 14 years of experience developing pioneering ELNs, Elsevier MDL has built an advanced Notebook system that uses the industry-leading MDL® Direct chemistry platform. MDL Direct (data cartridge technology) is the only chemistry search engine to combine full reaction transformation searching, unsurpassed chemistry sophistication and proven performance on databases with over five million reactions and at least 20 million molecules.

MDL Notebook builds a true reaction database from experiments, provides a powerful reaction-based enumerator for parallel chemistry and supports the full range of industry-leading MDL chemical representation and search features, including enhanced stereochemical representation.

The enhanced user interface is as easy to use as the familiar paper notebook while offering all the advantages of electronic data capture—including faster, more efficient searching, improved knowledge management, easier collaboration and enhanced productivity. The flexible, template-based approach to entering experimental procedures and data supports routine synthesis activities such as stoichiometry calculations and reaction drawing (with support for MDL® Draw and CambridgeSoft’s ChemDraw® software). Automatic protocol generation with built-in AutoText capability saves time, reduces the amount of typing required to capture data and produces standardized experimental reports that are easy to format and share with colleagues. A helpful experiment navigator function accelerates workflows by enabling researchers to quickly locate previously run or frequently used experiments.

MDL Notebook is part of a growing, new generation of MDL workflow tools available to researchers today. For more information, visit www.mdl.com.

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About Elsevier MDL
Elsevier MDL provides informatics, database and workflow solutions that accelerate successful life sciences R&D by improving the speed and quality of scientists’ decision making. Researchers around the world depend on Elsevier MDL for innovative and reliable discovery informatics software solutions and services augmented by 400 Elsevier chemistry and life sciences journals and related products. For more information, visit www.mdl.com. Elsevier is a world-leading publisher of scientific, technical and medical information products and services. For more information, visit www.elsevier.com. Elsevier is part of Reed Elsevier Group plc, a world-leading publisher and information provider. Reed Elsevier’s ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange). For more information, visit www.reedelsevier.com.

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Jean Holt

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Elsevier

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