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Beta Thalassemia Testing: G7 HPLC Analyzer Beta-Thalassemia Testing Mode Provides HbF and HbA2 measurement and Hemoglobinopathy Screening


South San Francisco, CA (TOSOH) May 26, 2009 -- Today, the measurement of hemoglobin A1c (HbA1c) is widely performed as a routine test using automated High Performance Liquid Chromatography (HPLC) with a short assay time. HPLC testing ( instruments are no longer solely dedicated for HbA1c testing. They are also used for HbF and HbA2 measurement and hemoglobinopathy screening.

Tosoh launched the Beta-thalassemia testing mode on the G7 in 2002 to provide high separation quality at an analysis time of 7.5 minutes per test. The G7 beta thalassemia testing mode quantifies HbF and HbA2 and provides presumptive identification of hemoglobin variants that cause hemoglobinopathies. The identification of hemoglobinopathy carriers is crucial since children born to these parents have a 25% chance of acquiring the disease.

The G7 HPLC Analyzer uses non-porous ion-exchange HPLC for rapid, accurate, and precise separation of the hemoglobin fractions. Analysis is carried out without any off-line specimen pretreatment. Separation is achieved by utilizing differences in ionic interactions between the cation exchange group on the column resin surface and the various hemoglobins and hemoglobin components.

Due to the increase in immigration of different ethnic groups, it is becoming more important to diagnose disorders of hemoglobin chain synthesis. Alternative methodologies for adequate presumptive identification usually require a combination of at least two techniques, one qualitative and one quantitative. Tosoh’s G7 beta thalassemia testing ( mode is the methodology of choice in today’s laboratories because you can efficiently obtain both qualitative and quantitative information at the same time.

For more information on Tosoh G7 HPLC Analyzer for HbA1c and Beta thalassemia testing, go to Tosoh Bioscience at


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