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Merck Reaffirms Cardiovascular Research Commitment


WHITEHOUSE STATION, N.J. - Merck & Co., Inc. today reaffirmed its commitment to discovering and developing novel treatments for a broad range of cardiovascular disorders, including atherosclerosis, hypertension, heart failure and metabolic syndrome. This year marks the 50th anniversary of the launch of the Company’s first major medicine for cardiovascular disease.

“We are committed to continuing our work in cardiovascular care,” said Dr. Peter S. Kim, president, Merck Research Laboratories. “Cardiovascular disease claims more than 17 million lives worldwide each year and remains the leading cause of death and a leading cause of disability. Merck’s cardiovascular research and development history makes us confident that more progress can be made to combat cardiovascular disease.”

More than 50 years after Merck introduced its first cardiovascular medicine, the Company has launched nearly 30 additional cardiovascular products, many of which were the first of their kind. By studying these medicines for new uses in landmark clinical trials, Merck has helped to establish new ways to treat cardiovascular disease.

“We’re proud of the innovations introduced by Merck and appreciate our partnership with cardiovascular specialists to help improve the lives of patients with cardiovascular risk,” said Dr. Richard Pasternak, vice president of cardiovascular clinical research, Merck Research Laboratories. “What we’re doing today and in the future will help us to deliver another 50 years of innovation in cardiovascular care.”

Building on scientific strengths
Today, as one of the world’s leading pharmaceutical research companies, Merck continues to invest nearly $5 billion a year in R&D to identify innovative new therapies for major unmet medical needs, including cardiovascular disease. The Company has more than 1,200 scientists and employees dedicated to fighting heart disease and eight new drug candidates in cardiovascular research and development for diseases such as heart failure, hypertension, the metabolic syndrome and dyslipidemia.

Besides the work occurring in its labs, Merck also is tapping the best science in the world as we pursue the next generation of innovations. “Collaborations with external partners, wherever in the world, are an integral and essential part of our long-term business and research strategy,” said Dr. Pasternak. “Our record and commitment to scientific excellence in cardiovascular care has made Merck a preferred partner for years – a status we intend to retain.”

The Company is forming external collaborations and partnerships in the field. Merck has collaborations with Actelion Pharmaceuticals to evaluate drugs for hypertension; Advinus Therapeutics to discover and develop drugs for metabolic syndrome; Arena Pharmaceuticals to develop novel agents for lipid management; NicOx to develop antihypertensive drugs; and the High Risk Plaque Initiative to advance the understanding and management of high-risk atherosclerotic plaque.

Merck also has research partnerships with numerous academic institutions including Oxford University (UK); Duke Clinical Research Institute; TIMI, Brigham and Women’s Hospital; Columbia University, Atherosclerosis Research Center; University of Pennsylvania; Baylor School of Medicine, University of Washington, and Montreal Heart Institute.

Cardiovascular education
Merck also supports cardiovascular education and independent research programs. For example, on a national level, Merck supports several American Heart Association (AHA) initiatives such as the Pharmaceutical Roundtable, Get With The Guidelines: Coronary Artery Disease and Stroke, “Go Red For Women”, and the AHA Annual Scientific Sessions and Exhibits. At the local level, Merck helps the AHA raise funds for cardiovascular research through Heart Walks and fundraising events.

Merck also sponsors The Giant Heart at the Franklin Institute in Philadelphia. The Giant Heart is an interactive exhibit that highlights human anatomy, physiology, health and wellness. Finally, 2009 will be the 29th consecutive year Merck has supported the American College of Cardiology’s Fellowship program.

Merck also provides financial grants and product donations to support independent research programs. For example, Merck has donated supplies of antihypertensive medicines to the National Marfan Foundation (NMF), which is seeking new treatments for Marfan Syndrome, a devastating illness that attacks connective tissues in the body. In April 2008, Merck’s efforts earned it the NMF’s Hero with a Heart Award for its commitment to innovation and patient care.

About Merck
Merck & Co., Inc. is a global research-driven pharmaceutical company dedicated to putting patients first. Established in 1891, Merck currently discovers, develops, manufactures and markets vaccines and medicines to address unmet medical needs. The Company devotes extensive efforts to increase access to medicines through far-reaching programs that not only donate Merck medicines but help deliver them to the people who need them. Merck also publishes unbiased health information as a not-for-profit service. For more information, visit

Forward-Looking Statement
This press release contains “forward-looking statements” as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements are based on management’s current expectations and involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements. The forward-looking statements may include statements regarding product development, product potential or financial performance. No forward-looking statement can be guaranteed and actual results may differ materially from those projected. Merck undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect Merck’s business, particularly those mentioned in the risk factors and cautionary statements in Item 1A of Merck’s Form 10-K for the year ended Dec. 31, 2007, and in any risk factors or cautionary statements contained in the Company’s periodic reports on Form 10-Q or current reports on Form 8-K, which the Company incorporates by reference.


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