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Crucell subsidiary awarded EU grant to develop malaria vaccine


Leiden, The Netherlands, December 22, 2006 - Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) today said the European Union had awarded a grant to its subsidiary toward the development of a Malaria vaccine. The €1.7 million grant was given to a consortium of four leading groups in the field of Malaria research including Etna Biotech, a fully-owned Crucell group company. Etna Biotech is based in Catania, Italy. The Malaria vaccine will be based on Crucell’s Recombinant Paramyxovirus technology.

“We are very delighted by the EU’s decision to offer this grant as it further demonstrates the importance for Recombinant Paramyxovirus technology toward the development of a malaria vaccine,” said Reinhard Glueck Etna Biotech’s CEO. “The EU grant is by no doubt an important step toward the development of a much-needed vaccine.”

About Recombitant Paramyxovirus Technology
The family of Paramyxoviruses includes common disease agents such as measles, mumps and parainfluenza. Live recombinant vaccines against these diseases have greatly contributed to their reduction, especially in developed countries. The use of live recombinant viruses in vaccines thus represents a well-established method of conferring immunity against the pathogen. With the advent of reverse genetics these viruses can also be used to introduce foreign genes, encoding foreign antigens, into their recombinant genome. For instance, insertion of an RNA segment into the recombinant measles genome encoding for an immune stimulatory protein derived from Plasmodium falciparum or HIV antigens could result in immune responses that could protect against malaria and AIDS. In such cases, because the recombinant viruses retain their high immunogenic properties, they induce a strong humoral and cellular response against both their own (measles) and the foreign (malaria or HIV) proteins. Crucell holds the exclusive rights to a patented cloning technique to engineer paramyxoviruses.

About Crucell
Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) is a biotechnology company focused on research, development and worldwide marketing of vaccines and antibodies that prevent and treat infectious diseases. Its vaccines are sold in public and private markets worldwide. Crucell’s core portfolio includes a vaccine against hepatitis B, a fully-liquid vaccine against five important childhood diseases, and a virosome-adjuvanted vaccine against influenza. Crucell also markets travel vaccines, such as the only oral anti-typhoid vaccine, an oral cholera vaccine and the only aluminum-free hepatitis A vaccine on the market. The Company has a broad development pipeline, with several Crucell products based on its unique PER.C6® production technology. The Company licenses this and other technologies to the biopharmaceutical industry. Important partners and licensees include DSM Biologics, sanofi aventis, GSK and Merck & Co. Crucell is headquartered in Leiden (the Netherlands), with subsidiaries in Switzerland, Spain, Italy, Sweden, Korea and the US. The Company employs over a 1000 people. For more information, please visit

Forward-looking statements
This press release contains forward-looking statements that involve inherent risks and uncertainties. We have identified certain important factors that may cause actual results to differ materially from those contained in such forward-looking statements. For information relating to these factors please refer to our Form 20-F, as filed with the U.S. Securities and Exchange Commission on July 6, 2006, and the section entitled “Risk Factors”. The Company prepares its financial statements under generally accepted accounting principles in the United States (US GAAP) and Europe (IFRS).


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