Vertex Pharmaceuticals Announces Webcast of its Presentation at the Bear Stearns 19th Annual Healthcare Conference

Cambridge, MA, September 8, 2006 –– Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) will webcast its corporate presentation at the Bear Stearns 19th Annual Healthcare Conference. Joshua Boger, Ph.D., President and Chief Executive Officer of Vertex, will deliver the presentation on Tuesday, September 12, 2006 at 2:00 p.m. EDT.

The presentation will be webcast live and may be accessed by visiting the Vertex website at www.vrtx.com. A replay of the webcast will also be available on the Company’s website until September 26, 2006. To access the webcast, go to Vertex’s website and select “Bear Stearns 19th Annual Healthcare Conference” from the ’Events Calendar.’ To ensure a timely connection, it is recommended that users register at least 15 minutes prior to the scheduled webcast.

About Vertex
Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company’s strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex’s product pipeline is principally focused on viral diseases, inflammation, autoimmune diseases and cancer. In collaboration with GlaxoSmithKline, Vertex co-discovered the HIV protease inhibitor, Lexiva.

Lexiva is a registered trademark of the GlaxoSmithKline group of companies.

Contact Information

Lora Pike

Manager, Investor Relations

Vertex Pharmaceuticals Incorporated

Contact via E-mail