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Many sudden cardiac arrests preceded by warning signs


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American Heart Association Meeting Report: Abstract 18987 (Hall F, Core 4, Poster Board: 4051)

Study Highlights:

  • More than half of the men who had a sudden cardiac arrest had symptoms up to a month before.


Embargoed until 9:30 a.m. CT/ 10:30 am. ET Tuesday, Nov. 19, 2013

DALLAS, Nov. 19, 2013 — Sudden cardiac arrest isn’t always so sudden, according to research presented at the American Heart Association’s Scientific Sessions 2013.

In a study of middle-age men in Portland, Oregon, more than half had possible warning signs up to a month before their hearts stopped abruptly.

Cardiac arrest occurs when the heart stops due to a failure in its electrical system. Patients can sometimes survive if they receive CPR immediately and a defibrillator is used quickly to shock the heart into a normal rhythm.

About 360,000 out-of-hospital cardiac arrests are reported each year in the United States, according to the American Heart Association. Only 9.5 percent of people who suffer a cardiac arrest outside the hospital survive.

“By the time rescuers get there, it’s much too late,” said Eloi Marijon, M.D., study lead author and a visiting scientist at Cedars-Sinai Heart Institute in Los Angeles.

The new research is part of the 11-year-old Oregon Sudden Unexpected Death Study, which involves 1 million people in the Portland metro area. Researchers gathered information about the symptoms and health history of men 35 to 65 years old who had out-of-hospital cardiac arrests in 2002-12.

Among 567 men who had out-of-hospital cardiac arrests, 53 percent had symptoms prior to the cardiac arrest. Of those with symptoms, 56 percent had chest pain, 13 percent had shortness of breath and 4 percent had dizziness, fainting or palpitations.

Almost 80 percent of the symptoms occurred between four weeks and one hour before the sudden cardiac arrest, he said.

Most men had coronary artery disease, but only about half had been tested for it before their cardiac arrest.

Researchers are conducting similar work in women.

“The lesson is, if you have these kinds of symptoms, please don’t blow them off,” said Sumeet Chugh, M.D., senior author and associate director for genomic cardiology at the Cedars-Sinai Heart Institute.“Go see your healthcare provider. Don’t waste time.”

Co-authors are Kyndaron Reinier, Ph.D., M.P.H.; Audrey Evanado, M.D.; Carmen Teodorescu, M.D., Ph.D.; Kumar Narayanan, M.D.; Adriana Huertas Vazquez, Ph.D.; Harpriya Chugh, B.E.; Katherine Jerger, B.S.; Ronald Mariani, E.M.T.P.; Eric Stecker, M.D., M.P.H.; Karen Gunson, M.D.; and Jonathan Jui, M.D., M.P.H. Author disclosures are on the abstract.

The Centers for Disease Control and Prevention, the American Heart Association and the Doris Duke Charitable Foundation funded the study.

Learn more about cardiac arrest and CPR.

Downloadable video/audio interviews, B-roll, animation and images related to this news release are on the right column of the release link at

http://newsroom.heart.org/news/many-sudden-cardiac-arrests-preceded-by-warning-signs?preview=16b82b9ed824d357ac20045c2008b3ae.

Video clips with researchers/authors of the studies will be added to the release link after embargo.

For more news from AHA Scientific Sessions 2013 follow us on Twitter @HeartNews#AHA13.

Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at www.heart.org/corporatefunding.

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