NIH-funded twin study finds occupational chemical exposure may be linked to Parkinsonís risk
A new research report contributes to the increasing evidence that repeated occupational exposure to certain chemical solvents raises the risk for Parkinsonís disease. Researchers analyzed the occupational histories of twins in which one of the pair developed the neurodegenerative disorder, and assessed that twinís likelihood of exposure to six chemicals previously linked to Parkinsonís. Of the six chemicals investigated, researchers concluded that two common chemical solvents, trichloroethylene (TCE) and perchloroethylene (PERC), are significantly linked to development of this disease. This study, supported in part by the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health, appears in the Nov. 14, 2011 issue of Annals of Neurology.
Parkinsonís disease is a movement disorder caused by the loss of brain cells that produce a molecule called dopamine. The primary symptoms of Parkinsonís are tremor, stiffness, slowed movement and impaired balance, and as these symptoms progress, patients may also develop difficulty walking, speaking or completing other activities of daily living. Genes play a role in Parkinsonís disease, but fewer than 10 percent of cases are due to a single gene mutation, and not all people with these mutations develop Parkinsonís, suggesting that environmental factors also contribute to the likelihood of developing the disease.
The researchers, led by Samuel Goldman, M.D., M.P.H. and Caroline Tanner, M.D., Ph.D. at the Parkinsonís Institute in Sunnyvale, Calif., collected the histories of 99 pairs of twins in which one of the pair developed Parkinsonís and the other twin did not. Since twins are so genetically similar, twin studies are especially useful in identifying environmental influences in disease. The twins were identified through the National Academy of Sciences/National Research Council World War II Veteran Twins Registry. Of the 99 pairs, half were genetically identical twins, and half were fraternal twins.
The study team assessed the twinsí lifetime work and hobby activities, specifically inquiring about occupational tasks such as electrical work, industrial machinery repair, and dry cleaning, which would potentially expose people to chemicals previously linked to Parkinsonís. The researchers also collected information on head injuries, which are suspected to increase Parkinsonís risk, and smoking history, which is reported to decrease Parkinsonís risk. Expert evaluators, unaware of which study subjects had Parkinsonís, reviewed this information and calculated lifelong exposure to six chemicals: TCE, PERC, carbon tetrachloride, n-hexane, xylene and toluene. Of these, TCE and PERC posed a notable risk for developing Parkinsonís.
ďThe potential importance is great, since both solvents persist in the environment and are commonly used,Ē said Dr. Goldman, ďParkinsonís was sixfold more common in twins exposed to TCE, and ninefold more common in twins exposed to TCE or PERC.Ē There was also a trend toward a tenfold increase in Parkinsonís disease in twins exposed to PERC alone.
In this study researchers looked only at occupational chemical exposure, and the association with job categories tended toward significance only for the industrial machinery repairer and industrial worker categories. However, the chemicals evaluated here are found outside industrial settings as well. PERC is the leading chemical used in garment dry cleaning. TCE is the most frequently reported organic groundwater contaminant, was once used as general anesthetic and coffee decaffeinating agent, and is still used widely as a metal degreasing agent.
TCE has also been linked to Parkinsonís by other research groups. Researchers at the University of Kentucky, Lexington, and the Kangwon National University in South Korea have reported an association between TCE and Parkinsonís in highly-exposed industrial workers, and have also demonstrated that TCE causes neurodegeneration in animal models.
The analysis described in this report expands on preliminary findings presented at the 2010 American Academy of Neurology meeting. The new paper quantifies the individualsí exposures to the chemicals in terms of successive years and cumulative exposure over their lifetime.
Dr. Tanner notes that while the association between chemical exposure and Parkinsonís is strong, one limitation of the research is the small number of individuals studied. "It will be important to replicate these results in additional populations with well-characterized exposure histories,Ē she commented.
Wendy Galpern, M.D., Ph.D., program director at NINDS, agreed that replication of these results is necessary. ďThis epidemiologic study is a noteworthy addition to our growing understanding of the association between environmental exposures and Parkinsonís disease,Ē Dr. Galpern said. ďThe identification of specific chemicals linked to this neurodegenerative disorder may have implications for disease prevention and an improved understanding of how Parkinsonís develops.Ē
The research was supported by NINDS/NIH, The Michael J. Fox Foundation for Parkinsonís Research, New York, Parkinsonís Unity Walk, Kingston, N.J., The Valley Foundation, Los Gatos, Calif., and James and Sharron Clark.
For more information about Parkinsonís Disease, visit the Parkinsonís Disease fact sheet on the NINDS website: www.ninds.nih.gov/PD
NINDS is the nationís leading funder of research on the brain and nervous system. The NINDS mission is to reduce the burden of neurological disease ó a burden borne by every age group, by every segment of society, by people all over the world.
About the National Institutes of Health (NIH): NIH, the nationís medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
Reference: Goldman SM et al. ďSolvent Exposures and Parkinson Disease Risk in TwinsĒ Annals of Neurology, published online November 14, 2011
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