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Crucell Files for Cancellation of Remaining Berna Biotech Minority Shares


Leiden, The Netherlands/Berne, Switzerland, April 12, 2006 - Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: SW CRX) and Berna Biotech AG (Swiss Exchange: BBIN) announced today that Crucell holds more than 98% of all issued shares of Berna Biotech. Crucell has filed for the cancellation of the remaining minority held shares in exchange for the consideration offered in the public exchange offer. This step is in line with previous announcements and the goal of fully integrating the two companies. The procedure, which is governed by the Swiss Act on Stock Exchanges and Securities Trading, is expected to last several months. Berna Biotech plans to have its shares delisted from the SWX Swiss Exchange upon completion of the cancellation procedure.

About Crucell
Crucell (Euronext and NASDAQ: CRXL; Swiss Exchange: SW CRX) is a biotechnology company focused on research, development, production and worldwide marketing of vaccines and antibodies that combat infectious diseases. The vaccines are sold in both private and public sectors. In Crucell’s portfolio hepatitis B vaccines and a virosomal influenza vaccine play an important role. Travel vaccines are also marketed including the only available oral anti-typhoid vaccine. The Company’s well-filled pipeline consists of early and late-stage products. Some of Crucell’s products are based on its unique PER.C6® production technology. The Company also licenses this and other technologies to the biopharmaceutical industry. Important partners and licensees include DSM Biologics, sanofi aventis, GSK and Merck & Co. Crucell is headquartered in Leiden, The Netherlands, has subsidiaries in Switzerland, elsewhere in Europe and Korea, and has approximately 900 employees. For more information, please visit

Forward-looking statements
This press release contains forward-looking statements that involve inherent risks and uncertainties. We have identified certain important factors that may cause actual results to differ materially from those contained in such forward-looking statements. For information relating to these factors please refer to our Form 20-F, as filed with the U.S. Securities and Exchange Commission on April 14, 2005, and the section entitled “Risk Factors”. The company prepares its financial statements under generally accepted accounting principles in the United States (US GAAP).


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