Crucell Adopts IFRS as Primary Reporting Method and Announces 2006 Financial Calendar

Leiden, The Netherlands, March 29, 2006 - Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: SW CRX) today announced that it will adopt IFRS as its primary financial reporting method from 2006. Crucell’s listing at Euronext Amsterdam and the Swiss Exchanges and related regulatory reporting requirements drive the Company’s decision to adopt IFRS at this time. The Company will continue to report its half-year and full-year financial results under US GAAP with a reconciliation to IFRS.

Crucell also announced the dates for its quarterly and annual financial results for 2006. The dates are as follows:

First Quarter: May 23, 2006
Second Quarter: August 29, 2006
Third Quarter: November 14, 2006
Annual Results: February 13, 2007

On each reporting date, the company will issue a press release at 08:00 CET, followed by a conference call at 14.00 CET, which will be webcast on Crucell’s website (www.crucell.com). Details and dial-in numbers for the conference calls will be announced two weeks prior to each reporting date by press release and will also be posted on the Company’s website.

Further, Crucell has announced that it will hold an Analyst briefing on April 27, 2006, at 14.00 CET (08:00 EST). This briefing will be targeted to analysts and will be webcast live.

About Crucell
Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: SW CRX) is a biotechnology company focused on research, development and worldwide marketing of vaccines and antibodies that prevent and treat infectious diseases. Its vaccines are sold in public and private markets worldwide. Crucell’s core portfolio includes vaccines against hepatitis B and virosomal influenza. Crucell also markets travel vaccines, such as the only oral anti-typhoid vaccine on the market. The Company has a broad development pipeline, including both early-stage products and products almost ready to go to market. Several Crucell products are based on its unique PER.C6® production technology. The Company licences this and other technologies to the biopharmaceutical industry. Important partners and licensees include DSM Biologics, sanofi aventis, GSK and Merck & Co. Crucell is headquartered in Leiden (the Netherlands), with subsidiaries in Switzerland, elsewhere in Europe, and in Korea. The Company employs about 1000 people. For more information, please visit www.crucell.com.

Contact Information

Harry Suykerbuyk

Director Investor Relations & Corporate Communications

Crucell N.V.

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