Nanobody Technology Made It Possible for Antibody Drugs to Cure Diseases

With the efforts of a large group of research members, Creative Biolabs, a US biotech company, successfully engineered single domain antibody from the heavy-chain antibodies found in camelids.

Compared with normal antibodies, single domain antibody, with only 10% of their molecular mass, is more flexible in terms of chemical property. Thanks to its tiny size and non-hydrophobic property, single domain antibody performs better in heat as well as acidic and alkali resistances.

“In the experiment on mice, their being able to remain viable and stable while passing through the mice’s digestive system has further proved the possibility of curing diseases by taking antibody drugs,” said Monica Müller, Ph.D., Senior Scientific Officer of Creative Biolabs.

Based on all these advantages, Creative Biolabs widened its services to meet more requirements from the market, including the construction of immunized single domain antibody libraries and synthetic camelised human single domain antibody libraries utilizing llama and camel and DNA synthesis respectively. Bio-panning of single domain antibodies libraries and large scale production of recombinant single domain antibodies are also the field of its expansion project.

Engineering and manufacturing of single domain antibody

Once the most potent clones are identified, their DNA sequence is codon-optimized and expressed in either bacteria cells or mammalian cells. Creative Biolabs is also able to engineer single domain antibodies in a wide range of formats, including unique multivalent, bivalent and bi-specific molecules. Creative Biolabs is experienced in conducting affinity maturation of single domain antibody. Especially, quantitative library sorting by phage display or yeast surface display is utilized for the affinity of single domain antibodies.

Other featured single domain antibody services include the following ones.

   Single Domain Antibody Library Services
   Single Domain Antibody Affinity Maturation Services
   Human or Humanized Single Domain Antibody Production Services
   Bispecific Production
   Single domain antibody Discovery against Membrane Proteins by DNA Immunization 
   Anti-BBB single domain antibody Discovery Service
   De Novo single domain antibody Sequencing Service

Lear more about single domain antibody from Creative Biolabs.

About Creative Biolabs

Creative Biolabs is a professional service provider focuses on the field of single domain antibody production and single domain antibody engineering. It is specialized in generating single domain antibodies against any targets. In addition, it also provides a wide range of other services, including construction of immunized single domain antibody libraries utilizing llama and camel, construction of synthetic camelised human single domain antibody libraries with DNA synthesis, bio-panning of single domain antibodies libraries, large scale production of recombinant single domain antibodies, etc. Learn more about Creative Biolabs.

Contact
Monica Müller
contact@creative-biolabs.com
(631) 871-5806

Contact Information

Olivia Blake

Senior Scientific Officer

Creative Biolabs

(1) 631-8715806

contact@creative-biolabs.com